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1

In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb

Oihana Murillo, Juan Dubrot, Asís Palazón, Ainhoa Arina, Arantza Azpilikueta, Carlos Alfaro, Sarai Solano, María C. Ochoa, Carmen Berasain, Izaskun Gabari, José. L. Pérez-Gracia, Pedro Berraondo, Sand

Journal:

European Journal of Immunology

Année:

2009

Langue:

english

Fichier:

PDF, 532 KB

english, 2009

2

Dendritic cells adhere to and transmigrate across lymphatic endothelium in response to IFN-α

Ana Rouzaut, Saray Garasa, Álvaro Teijeira, Iranzu González, Ivan Martinez-Forero, Natalia Suarez, Esther Larrea, Carlos Alfaro, Asís Palazón, Juan Dubrot, Sandra Hervás-Stubbs, Ignacio Melero

Journal:

European Journal of Immunology

Année:

2010

Langue:

english

Fichier:

PDF, 578 KB

english, 2010

3

Effects of IFN-α as a signal-3 cytokine on human naïve and antigen-experienced CD8+ T cells

Sandra Hervas-Stubbs, Jose-Ignacio Riezu-Boj, Iranzu Gonzalez, Uxua Mancheño, Juan Dubrot, Arantza Azpilicueta, Izaskun Gabari, Asis Palazon, Alicia Aranguren, Juan Ruiz, Jesus Prieto, Esther Larrea,

Journal:

European Journal of Immunology

Année:

2010

Langue:

english

Fichier:

PDF, 888 KB

english, 2010

4

The combined actions of NK and T lymphocytes are necessary to reject an EGFP+ mesenchymal tumor through mechanisms dependent on NKG2D and IFNγ

Ainhoa Arina, Oihana Murillo, Sandra Hervás-Stubbs, Arantza Azpilikueta, Juan Dubrot, Iñigo Tirapu, Eduardo Huarte, Carlos Alfaro, Jose L. Pérez-Gracia, Gloria González-Aseguinolaza, Pablo Sarobe, Jua

Journal:

International Journal of Cancer

Année:

2007

Langue:

english

Fichier:

PDF, 742 KB

english, 2007

5

Intratumoral injection of interferon-α and systemic delivery of agonist anti-CD137 monoclonal antibodies synergize for immunotherapy

Juan Dubrot, Asis Palazón, Carlos Alfaro, Arantza Azpilikueta, María Carmen Ochoa, Ana Rouzaut, Iván Martinez-Forero, Alvaro Teijeira, Pedro Berraondo, Agnes Le Bon, Sandra Hervás-Stubbs, Ignacio Mele

Journal:

International Journal of Cancer

Année:

2011

Langue:

english

Fichier:

PDF, 1.61 MB

english, 2011

6

Synergistic effects of CTLA-4 blockade with tremelimumab and elimination of regulatory T lymphocytes in vitro and in vivo

Natalia Suarez, Carlos Alfaro, Juan Dubrot, Asis Palazon, Elixabet Bolaños, Lorena Erro, Sandra Hervas-Stubbs, Ivan Martinez-Forero, Aizea Morales-Kastresana, Salvador Martin-Algarra, Bruno Sangro, Fe

Journal:

International Journal of Cancer

Année:

2011

Langue:

english

Fichier:

PDF, 1.69 MB

english, 2011

7

Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects in this organ

Juan Dubrot, Francisca Milheiro, Carlos Alfaro, Asis Palazón, Ivan Martinez-Forero, Jose L. Perez-Gracia, Aizea Morales-Kastresana, José L. Romero-Trevejo, María C. Ochoa, Sandra Hervás-Stubbs, Jesús

Journal:

Cancer Immunology, Immunotherapy

Année:

2010

Langue:

english

Fichier:

PDF, 888 KB

english, 2010

8

Delivery of immunostimulatory monoclonal antibodies by encapsulated hybridoma cells

Juan Dubrot, Aitziber Portero, Gorka Orive, Rosa María Hernández, Asis Palazón, Ana Rouzaut, Jose L. Perez-Gracia, Sandra Hervás-Stubbs, Jose Luis Pedraz, Ignacio Melero

Journal:

Cancer Immunology, Immunotherapy

Année:

2010

Langue:

english

Fichier:

PDF, 900 KB

english, 2010

9

Interleukin-15 liver gene transfer increases the number and function of IKDCs and NK cells

Arina, A, Murillo, O, Dubrot, J, Azpilikueta, A, Gabari, I, Perez-Gracia, J L, Alfaro, C, Berasain, C, Prieto, J, Ferrini, S

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 395 KB

english, 2008

10

Proliferating NK cells in response to IL-15 do not upregulate surface B220 in vivo

Murillo, O, Ochoa, M C, Arina, A, Gabari, I, Dubrot, J, Hervas-Stubbs, S, Melero, I

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 215 KB

english, 2009

11

106 Interferon-Producing Killer Dendritic Cells and Natural Killer Cells Response to Interleukin-15 Liver Gene Transfer

Oihana Murillo, Ainhoa Arina, Juan Dubrot, Arantza Azpilikueta, Izaskun Gabari, Carlos Alfaro, Carmen Berasain, Sandra Hervas-Stubbs, José L. Perez Gracia, Jesús Prieto, Ignacio Melero, Silvano Ferrin

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 49 KB

english, 2007

12

PS2-082 Immunological effects of gene transfer with the sushi domain of IL-15Rα and a chimeric protein consisting of IL-15 fused to apolipoprotein A-1

M.C. Ochoa, J. Fioravanti, E.H. Duitman, J. Medina-Echeverz, A. Palazon, A. Arina, J. Dubrot, C. Alfaro, A. Morales-Kastresana, O. Murillo, S. Hervas-Stubbs, J. Prieto, P. Berraondo, I. Melero

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 46 KB

english, 2011

13

Porphobilinogen deaminase over-expression in hepatocytes, but not in erythrocytes, prevents accumulation of toxic porphyrin precursors in a mouse model of acute intermittent porphyria

Carmen Unzu, Ana Sampedro, Itsaso Mauleón, Lucía Vanrell, Juan Dubrot, Rafael Enríquez de Salamanca, Gloria González-Aseguinolaza, Ignacio Melero, Jesús Prieto, Antonio Fontanellas

Journal:

Journal of Hepatology

Année:

2010

Langue:

english

Fichier:

PDF, 733 KB

english, 2010

14

Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies

Ignacio Melero, Oihana Murillo, Juan Dubrot, Sandra Hervás-Stubbs, José L. Perez-Gracia

Journal:

Trends in Pharmacological Sciences

Année:

2008

Langue:

english

Fichier:

PDF, 842 KB

english, 2008

15

Absence of surface expression of CD137 (4-1BB) on Myeloid-derived suppressor cells

J. Dubrot, A. Azpilikueta, C. Alfaro, O. Murillo, A. Arina, P. Berraondo, S. Hervás-Stubbs, I. Melero

Journal:

Année:

2007

Fichier:

PDF, 143 KB

2007

16

Polly Matzinger's “danger model” finds its predicted danger-denoting self moieties

Asis Palazón, Juan Dubrot, Iván Martinez-Forero, Ana Rouzaut-Subirá, Carmen Ochoa, José Luis Perez-Gracia, Sandra Hervás-Stubbs, Ignacio Melero

Journal:

Année:

2008

Fichier:

PDF, 93 KB

2008

17

Interferon producing killer dendritic cells (IKDC): A matter of controversy

Aizea Morales, Carmen Ochoa, Asís Palazón, Juan Dubrot, Belén Palencia, Carlos Alfaro, Natalia Suarez, Iván Martínez Forero, Sandra Hervás-Stubbs, Ignacio Melero

Journal:

Année:

2010

Fichier:

PDF, 97 KB

2010

18

Immunotherapeutic Synergy Between Anti-CD137 mAb and Intratumoral Administration of a Cytopathic Semliki Forest Virus Encoding IL-12

Quetglas, José I, Dubrot, Juan, Bezunartea, Jaione, Sanmamed, Miguel F, Hervas-Stubbs, Sandra, Smerdou, Cristian, Melero, Ignacio

Journal:

Molecular Therapy

Année:

2012

Langue:

english

Fichier:

PDF, 1.85 MB

english, 2012

19

Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes

Alfaro, C, Suarez, N, Gonzalez, A, Solano, S, Erro, L, Dubrot, J, Palazon, A, Hervas-Stubbs, S, Gurpide, A, Lopez-Picazo, J M, Grande-Pulido, E, Melero, I, Perez-Gracia, J L

Journal:

British Journal of Cancer

Année:

2009

Langue:

english

Fichier:

PDF, 354 KB

english, 2009

20

Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4+ T cell tolerance

Dubrot, J., Duraes, F. V., Potin, L., Capotosti, F., Brighouse, D., Suter, T., LeibundGut-Landmann, S., Garbi, N., Reith, W., Swartz, M. A., Hugues, S.

Journal:

Journal of Experimental Medicine

Année:

2014

Langue:

english

Fichier:

PDF, 2.92 MB

english, 2014

21

Agonist Anti-CD137 mAb Act on Tumor Endothelial Cells to Enhance Recruitment of Activated T Lymphocytes

Palazon, A., Teijeira, A., Martinez-Forero, I., Hervas-Stubbs, S., Roncal, C., Penuelas, I., Dubrot, J., Morales-Kastresana, A., Perez-Gracia, J. L., Ochoa, M. C., Ochoa-Callejero, L., Martinez, A., L

Journal:

Cancer Research

Année:

2011

Langue:

english

Fichier:

PDF, 1.29 MB

english, 2011

22

Cellular liaisons of natural killer lymphocytes in immunology and immunotherapy of cancer

Arina, Ainhoa, Murillo, Oihana, Dubrot, Juan, Azpilikueta, Arantza, Alfaro, Carlos, Pérez-Gracia, Jose L, Bendandi, Maurizio, Palencia, Belen, Hervás-Stubbs, Sandra, Melero, Ignacio

Journal:

Expert Opinion on Biological Therapy

Année:

2007

Langue:

english

Fichier:

PDF, 366 KB

english, 2007

23

Strict Requirement for Vector-Induced Type I Interferon in Efficacious Antitumor Responses to Virally Encoded IL12

Melero, I., Quetglas, J. I., Reboredo, M., Dubrot, J., Rodriguez-Madoz, J. R., Mancheno, U., Casales, E., Riezu-Boj, J. I., Ruiz-Guillen, M., Ochoa, M. C., Sanmamed, M. F., Thieblemont, N., Smerdou, C

Journal:

Cancer Research

Année:

2015

Langue:

english

Fichier:

PDF, 2.05 MB

english, 2015

24

Therapeutic Antitumor Efficacy of Anti-CD137 Agonistic Monoclonal Antibody in Mouse Models of Myeloma

Murillo, O., Arina, A., Hervas-Stubbs, S., Gupta, A., McCluskey, B., Dubrot, J., Palazon, A., Azpilikueta, A., Ochoa, M. C., Alfaro, C., Solano, S., Perez-Gracia, J. L., Oyajobi, B. O., Melero, I.

Journal:

Clinical Cancer Research

Année:

2008

Langue:

english

Fichier:

PDF, 657 KB

english, 2008

25

Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ T cells

Hepworth, M. R., Fung, T. C., Masur, S. H., Kelsen, J. R., McConnell, F. M., Dubrot, J., Withers, D. R., Hugues, S., Farrar, M. A., Reith, W., Eberl, G., Baldassano, R. N., Laufer, T. M., Elson, C. O.

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 1.66 MB

english, 2015

26

Ag-Presenting CpG-Activated pDCs Prime Th17 Cells That Induce Tumor Regression

Guery, L., Dubrot, J., Lippens, C., Brighouse, D., Malinge, P., Irla, M., Pot, C., Reith, W., Waldburger, J.-M., Hugues, S.

Journal:

Cancer Research

Année:

2014

Langue:

english

Fichier:

PDF, 986 KB

english, 2014

27

Palettes of Vaccines and Immunostimulatory Monoclonal Antibodies for Combination

Melero, I., Martinez-Forero, I., Dubrot, J., Suarez, N., Palazon, A., Chen, L.

Journal:

Clinical Cancer Research

Année:

2009

Langue:

english

Fichier:

PDF, 219 KB

english, 2009

28

Lysine 63 Polyubiquitination in Immunotherapy and in Cancer-promoting Inflammation

Martinez-Forero, I., Rouzaut, A., Palazon, A., Dubrot, J., Melero, I.

Journal:

Clinical Cancer Research

Année:

2009

Langue:

english

Fichier:

PDF, 424 KB

english, 2009

29

Intensive Pharmacological Immunosuppression Allows for Repetitive Liver Gene Transfer With Recombinant Adenovirus in Nonhuman Primates

Fontanellas, Antonio, Hervás-Stubbs, Sandra, Mauleón, Itsaso, Dubrot, Juan, Mancheño, Uxua, Collantes, María, Sampedro, Ana, Unzu, Carmen, Alfaro, Carlos, Palazón, Asis, Smerdou, Cristian, Benito, Alb

Journal:

Molecular Therapy

Année:

2010

Fichier:

PDF, 1.15 MB

2010

30

Intensive Pharmacological Immunosuppression Allows for Repetitive Liver Gene Transfer With Recombinant Adenovirus in Nonhuman Primates

Fontanellas, Antonio, Hervás-Stubbs, Sandra, Mauleón, Itsaso, Dubrot, Juan, Mancheño, Uxua, Collantes, María, Sampedro, Ana, Unzu, Carmen, Alfaro, Carlos, Palazón, Asis, Smerdou, Cristian, Benito, Alb

Journal:

Molecular Therapy

Année:

2010

Langue:

english

Fichier:

PDF, 1.15 MB

english, 2010

31

Cardiotrophin-1 determines liver engraftment of syngenic colon carcinoma cells through an immune system-mediated mechanism

Bustos, Matilde, Dubrot, Juan, Martinez-Anso, Eduardo, Larequi, Eduardo, Castaño, David, Palazon, Asis, Belza, Idoia, Sanmamed, Miguel F., Perez-Gracia, Jose Luis, Ortiz de Solorzano, Carlos, alfaro,

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.30 MB

english, 2012

32

pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation

Duraes, Fernanda V., Lippens, Carla, Steinbach, Karin, Dubrot, Juan, Brighouse, Dale, Bendriss-Vermare, Nathalie, Issazadeh-Navikas, Shohreh, Merkler, Doron, Hugues, Stephanie

Journal:

Journal of Autoimmunity

Année:

2016

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2016

33

IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity

Lippens, Carla, Duraes, Fernanda V., Dubrot, Juan, Brighouse, Dale, Lacroix, Mathilde, Irla, Magali, Aubry-Lachainaye, Jean-Pierre, Reith, Walter, Mandl, Judith N., Hugues, Stéphanie

Journal:

Journal of Autoimmunity

Année:

2016

Langue:

english

Fichier:

PDF, 1.68 MB

english, 2016

34

The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells

Menezes, Shinelle, Melandri, Daisy, Anselmi, Giorgio, Perchet, Thibaut, Loschko, Jakob, Dubrot, Juan, Patel, Rajen, Gautier, Emmanuel L., Hugues, Stéphanie, Longhi, M. Paula, Henry, Jake Y., Quezada,

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 4.06 MB

english, 2016

35

Pannexin1 links lymphatic function to lipid metabolism and atherosclerosis

Molica, Filippo, Meens, Merlijn J., Dubrot, Juan, Ehrlich, Avigail, Roth, Christel L., Morel, Sandrine, Pelli, Graziano, Vinet, Laurent, Braunersreuther, Vincent, Ratib, Osman, Chanson, Marc, Hugues,

Journal:

Scientific Reports

Année:

2017

Langue:

english

Fichier:

PDF, 10.25 MB

english, 2017

36

Carcinoma-Derived Interleukin-8 Disorients Dendritic Cell Migration Without Impairing T-Cell Stimulation

Alfaro, Carlos, Suárez, Natalia, Martínez-Forero, Ivan, Palazón, Asís, Rouzaut, Ana, Solano, Sarai, Feijoo, Esperanza, Gúrpide, Alfonso, Bolaños, Elixabet, Erro, Lorena, Dubrot, Juan, Hervás-Stubbs, S

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 977 KB

english, 2011

37

Fundamental Roles of the Golgi-Associated Toxoplasma Aspartyl Protease, ASP5, at the Host-Parasite Interface

Hammoudi, Pierre-Mehdi, Jacot, Damien, Mueller, Christina, Di Cristina, Manlio, Dogga, Sunil Kumar, Marq, Jean-Baptiste, Romano, Julia, Tosetti, Nicolò, Dubrot, Juan, Emre, Yalin, Lunghi, Matteo, Copp

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 14.13 MB

english, 2015

38

Modes of Antigen Presentation by Lymph Node Stromal Cells and Their Immunological Implications

Hirosue, Sachiko, Dubrot, Juan

Journal:

Frontiers in Immunology

Année:

2015

Langue:

english

Fichier:

PDF, 3.16 MB

english, 2015

39

Macroautophagy in Endogenous Processing of Self- and Pathogen-Derived Antigens for MHC Class II Presentation

Duraes, Fernanda V., Niven, Jennifer, Dubrot, Juan, Hugues, Stéphanie, Gannagé, Monique

Journal:

Frontiers in Immunology

Année:

2015

Langue:

english

Fichier:

PDF, 916 KB

english, 2015

40

Shaping of Peripheral T Cell Responses by Lymphatic Endothelial Cells

Humbert, Marion, Hugues, Stéphanie, Dubrot, Juan

Journal:

Frontiers in Immunology

Année:

2017

Langue:

english

Fichier:

PDF, 1.43 MB

english, 2017

41

Dendritic Cell Migration Toward CCL21 Gradient Requires Functional Cx43

Ruez, Richard, Dubrot, Juan, Zoso, Alice, Bacchetta, Marc, Molica, Filippo, Hugues, Stéphanie, Kwak, Brenda R., Chanson, Marc

Journal:

Frontiers in Physiology

Année:

2018

Langue:

english

Fichier:

PDF, 2.45 MB

english, 2018

42

Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade

Ishizuka, Jeffrey J., Manguso, Robert T., Cheruiyot, Collins K., Bi, Kevin, Panda, Arpit, Iracheta-Vellve, Arvin, Miller, Brian C., Du, Peter P., Yates, Kathleen B., Dubrot, Juan, Buchumenski, Ilana,

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 9.86 MB

english, 2018